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they removed his stem cells, corrected two missing DNA letters and reimplanted the cells after chemotherapy.
now 66% of his neutrophils function normally.
no major side effects (for now).
this is a world first
2/
AI is advancing CRISPR by optimizing guide RNAs and predicting outcomes, mainly for single-gene disorders like sickle cell anemia. Editing complex traits like eye color, height, or brain size, which involve many genes, is far more challenging and not yet feasible. These polygenic
People have done that on youtube since like before covid.
The health conspiracy clowns are going to have a field day with this.
~1,000 patients have received gene editing for many different diseases now.
This was the first for prime editing however.
Lots of diseases are being cured!
SCD
HAE
ATTR
AATD and many more!
Ppl thinking about the impact of AI but overlooking biotech between crispr advancement, bio computers, and synthetic biology the best time to be a curious and creative human
epigenome editing is mostly a combinatorial problem now right? What’s are the arguments for why the huge buildout of HPC doesn’t cause a boom in the sector?
Genetic diseases will be a thing of the past sooner than most realize thanks to amazing technology like CRISPR.
Irreconcilable documentary explores why people disagree on COVID vaccine safety. Share/watch with those whom you disagree!
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I am hoping that they will be able to do this for male pattern baldness
Wonder if this would work for common blood cancers and sickle cell.
i could see the US being the first to use this for disease, but china will be the first to use it to create superhumans
Human code—edited.
The line between biology and software is dissolving.
We’re not just healing—we’re rewriting.
This teen didn’t just survive disease.
He became a prototype for the post-human era.
Welcome to the age of programmable life.
i like these posts more some other techno optimist posts bcz they’re based on published results. ty for posting
Bone marrow stem cell modification is unfortunately the only way to do cell or gene therapy that works. This is entirely due to the unique homing properties of marrow stem cells. They can cmove back into the inner lining of stem cells immediately flanking the interior of the
Holy shit. My son was born with a genetic syndrome and needs to use a ventilator every day. This technology could potentially cure him. Thank you so much for sharing.
Such a crazy timeline we are living in. How could you possibly not be excited about the future?
How crazy is this. Do you think this tech will exist in our lifetime for recreational uses like disabling the gene responsible for myostatin production?
I wish I could get my cancer vaccine patent in front of peer review without accreditation.
Hope the US govt waits at least a decade before mandating we take *this* gene therapy.
This is pretty insane that it's possible to do this. I vividly remember when they first mapped human DNA. I suppose they cloned Dolly the sheep in the 90s. 
The real question on everyone mind, can it make my dick an 18” coke can?
Sickle cell is also a letter or two edits. Do you know if we have human trials going for sickle cell disease?
Preble Jefferson can see 5 seconds into the future. When government agencies become aware of his skill, he'll do whatever it takes to protect his family.
“Calling this a thriller is a bit reductive...The most interesting novel I’ve read in a long time.” --JDC
They used chemo to destroy his cells, I’m guessing? Erase and reboot? Depending on the chemo, it’s going to most likely give him bone cancer or blood cancer later in life.
Sounds like another way to make him sick and dependent.
I’d much rather see this used to get to distant
All the silly cultural discourse is about to be nullified. We won’t argue with or disapprove of each other anymore. We’re all about to be perfect superheroes with no conflicts or bitching about each other. No more gossip either. I’m excited.
Robotic ai precision doctors will make advance healthcare affordable
Nueralink surgery is already only done by a robot
Please please God and scientists cure rheumatoid arthritis. I hate it this stupid autoimmune disease
Not the first though. They had a clinical trials 2-3 years ago where they cured 6 people with Transthyretin (TTR) Amyloidopathy. Very impressive that one.
Can I get my DNA rewritten to make me less susceptible to rheumatoid arthritis? It'd be nice to make the inflammation go away so I can think again.
Good result for sure, but this needs to be regulated like nothing else has ever been regulated before
Thing is, this isn't a world first but first accepted case. China did this in 2018, against the wishes of the scientific community, to change eye colors on twins & a few other items if I recall correctly.
OMG I hope this can also cure digestive issues like Ulcerative Colitis too. The fear of shitting yourself if you aren't close to a bathroom is something no one should suffer.
That's crazy. Sounds like something that would cost millions of dollars in the u.s.
Can't wait to hack into my body and give myself a myostatin deficiency for infinite gains
Amazing, but wouldn't the old cells naturally take over? Why would these new genes out pace the old ones?
Does this procedure have to be continually given in the future?
CRISPR causes further problems down the line. They know how to remove a piece of DNA but they have no idea of long term effects.
To be honest, for people with really severe gene defects that make every day a major challenge, that is actually good.
I only worry that it's going to be used for minor and cosmetic shit.
I'm sure he feels like an entirely new person. Does it come with a new birth certificate?
Genes have "memories". Those stem cells will revert back to their original coding.
The kid's going to need ongoing biohacking for life.
when they try to fix things they don't know the origin of problem, and what gene compense :
GIF
how do they rewrite genes in real flesh person's and it stays active???
