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1/ Insane: A single injection into the inner ear reversed deafness in all ten patients. Some started hearing again within weeks. Gene therapy just crossed a threshold we thought was still years away. Lets dig into this breakthrough and how it works 🧵
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David Watson 🥑
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2/ People born with OTOF gene mutations can't produce otoferlin, a protein the inner ear needs to send sound signals to the brain. Without it, cochlear implants are the only option. There has never been a way to fix the root cause.
3/ Researchers injected a synthetic virus carrying a working copy of the OTOF gene directly into the cochlea. One shot. The virus delivers the genetic blueprint, the body starts producing otoferlin, and sound signals begin reaching the brain again.
4/ Average hearing improved from 106 dB to 52 dB. A seven-year-old girl went from deaf to having conversations with her mother in four months. And for the first time, the therapy also worked in teenagers and adults, not just young children.
5/ The team is already targeting GJB2 and TMC1, two more common deafness genes, with promising animal results. We are watching gene therapy move from rare-disease fix to a platform that could one day treat most forms of genetic hearing loss.
Researchers also investigating whether stem cells can regenerate damaged inner-ear nerves and improve hearing.
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we’re finally starting to debug the wetware. a single injection acting as a firmware update for the inner ear is the kind of leap that makes most tech breakthroughs look like css tweaks
I need to touch grass. I first read this as: "A single prompt injection..." But as a person who is half-deaf, this is great news and progress. Thank you for sharing.
these are thr types of research you should fund nerulink is good maybe now for brain damage or something u got anything up your sleeve

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OpenAI's new image model GPT-Image-2 has leaked It seems to have extremely good world knowledge and great text rendering Possibly better than Nano Banana Pro It's on under code names: - maskingtape-alpha - gaffertape-alpha - packingtape-alpha
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Three new image models have hit the Arena 👀 They're named maskingtape, packingtape, and gaffertape. I'm particularly impressed by the amount of "world knowledge" these models have - as well as the text rendering. These were simple prompts: "average engineer's screen" and
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Holy, OpenAI's GPT-image-2 will crush everything. I remember when everyone laughed at the GPT image because it couldn't generate a proper world map. Those days are over. And even the YouTube image is now indistinguishable from reality. Holy moly.
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OpenAI's new image model GPT-Image-2 has leaked It seems to have extremely good world knowledge and great text rendering Possibly better than Nano Banana Pro It's on @arena under code names: - maskingtape-alpha - gaffertape-alpha - packingtape-alpha
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