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SSRIs May Speed Up Cognitive Decline A large study of 18,740 dementia patients found that those taking antidepressants experienced faster cognitive decline compared to those who were not medicated. Selective serotonin reuptake inhibitors (SSRIs), particularly escitalopram, citalopram, and sertraline, were associated with the greatest deterioration. Mirtazapine, which works differently from SSRIs, had a milder impact on cognitive function. While depression itself can worsen dementia symptoms, it remains unclear whether the decline is due to the medication or the underlying condition. Researchers emphasize the need for more individualized treatment approaches to balance mental health benefits with potential cognitive risks. Future studies will explore whether specific dementia types or biomarkers influence antidepressant effects.
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Neuroscience News
@NeuroscienceNew
SSRIs May Speed Up Cognitive Decline A new study based on data from 18,740 dementia patients suggests that antidepressants may accelerate cognitive decline. Researchers found that patients taking antidepressants, particularly SSRIs like escitalopram, citalopram, and sertraline,
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Neuroscience News
@NeuroscienceNew
Key Facts 1 - Faster Cognitive Decline: Dementia patients on antidepressants showed greater cognitive deterioration over time. 2 - SSRI Impact: Escitalopram, citalopram, and sertraline were linked to the fastest decline, while mirtazapine had a milder effect. 3 - Need for
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Barry Anderson
@BarryAn27934981
FROM my estensive RESEARCH on the SUBJECT SUGAR is so DEADLY to the HUMAN BRAIN over time including the some of the Pharmacy Drugs and the Alcahol combination with lack of the hormone D-3 derived from SUN exposure .
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MindScape Retreat: Ibogaine Treatment Center
@ibogaineretreat
Response: This is another reason why alternative treatments like Ibogaine should be explored for depression, especially in neurodegenerative conditions. SSRIs may provide short-term symptom relief, but their long-term impact on cognitive decline, serotonin receptor
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Grizz
@Grizz_Khalifa31
Hi yall, neuroscience PhD here. This isn’t published (yet supposedly) so it is NOT PEER REVIEWED OR SCRUTINIZED. Nor do they really tell you enough to know how well the study was designed, what they controlled for, or how the analysis was done. At times like this I expect more
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Mike G
@gribbo586
It’s an observational study which has its weaknesses (lack of control groups, potential for bias, doesn’t test for confounders). I’m open to the possibility of ssri’s having unintended consequences but I wouldn’t base it off this study.
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Adam Devine
@Adam1961Devine
"While depression itself can worsen dementia symptoms, it remains unclear whether the decline is due to the medication or the underlying condition." Then there's that...
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drPatricioReyPsiquiatra
@drpatriciorey
Correlación no implica causalidad: en la progresión del deterioro cognitivo en demencia hay que mensurar aparte de los fármacos otras variables como tipo de demencia, edad de inicio, afectación conductual, autonomía funcional, CI previo, alteración cronobiológica, comorbilidades
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Andrew D. Huberman, Ph.D.
@hubermanlab
Exposing your skin to long wavelength light from sunlight or red/IR device can significantly improve your blood glucose regulation. Wild! but makes sense given its impact on mitochondria and metabolism.
@RogerSeheult
on the Huberman Lab podcast out now.
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Neuroscience News
@NeuroscienceNew
Short-Term Junk Food Diet Reduces Brain’s Insulin Sensitivity A new study shows that just five days of consuming high-calorie, processed foods can reduce the brain’s sensitivity to insulin, a key regulator of appetite and metabolism. Researchers found that even in healthy
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This shows a brain and food.
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