"Patients who go off GLP-1's often gain the weight back" somehow got changed to "Everybody who stops taking the fat drug gets fat again" when the latter does not appear to be the case. epicresearch.org/articles/many-
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I had seen data showing that the weight regain was not complete, but I'm surprised to see continued weight loss in such a large percentage of users.
It's critics of the drugs (among others) that will tell you that losing weight is about lifestyle change. For some, drugs help them make that change. Once they have the right habits.
Also, this is just one year. Five years, might tell a different story. These studies are always, always confounded. You can't look at the graph and really see the picture.
My personal experience with weight loss the traditional way is that it takes 2-3 years and then starts to come back. I won't be surprised if that's the case here for those that don't start gaining weight immediately.
It might be that it's a drug you go off and on as warranted.
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Sounds about right, half of the people are lazy and don't count macros or exercise and half do and do well after.
The "critics" of the drugs usually aren't even doctors that see these patients the most. Their opinions are irrelevant
Looking closer at this, I have to wonder if/how they know whether the patients truly stopped.
I'd worry many patients "stopped"... using the name brand drug from a pharmacy, once they lost coverage by no longer being obese. And just switched to buying compounded versions OOP.
this Apr 2025 review says "Current evidence from trials suggests that weight is regained rapidly for patients who discontinue GLP-1RA treatment", but all the cited studies have a similar result of on average 65% regain - so still significant net loss
pmc.ncbi.nlm.nih.gov/articles/PMC12
I think a lot of the worry about staying on GLP-1’s will subside when we get it in pill form and generics.
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