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In that chart, you can see the response to a meal.
At baseline, blood sugar levels go dangerously high (right) because participants don't produce insulin at all (proxied by C-peptide levels, left).
But notice the blood sugar and C-peptide levels after treatment:
With treatment, the patients kept getting better and better.
Their pancreatic function improved over time, and they became more and more able to handle food, and to do so without the need to inject insulin.
In a little over a month after treatment, the A1C levels of the sample shifted towards the maximum recommended level, and shortly thereafter, they dropped down to prediabetic levels.
They weren't amazing by any means, but this is an incredible improvement for type-1 sufferers.
More importantly, it became clear that the treatment allowed people to maintain their blood glucose at levels that were pretty much acceptable, most of the time.
That is why becoming insulin-independent after this nearly one-shot therapy was possible for most of them.
Now, you might've noticed that in those last two graphs, there's a section saying "Participant died".
Two patients did die, but not due to this therapy.
The first broke trial protocol due to a serious injury and died from meningitis. The second was due to pre-existing dementia.
Those deaths are tragic, but they do not speak against the success of this therapy.
And this therapy seems to be miraculous.
A single infusion and three days of immunosuppression resulted in everyone being cured of the need for insulin. Type-1 diabetes was beaten.
The next steps for this therapy are simple.
Firstly, ramp it up. I think the government should throw money at this.
Secondly, the government has the ability to do some deregulation to make this very cheap. I'm not providing details here right now. This is in the HHS' hands.
If done right, perhaps we'll be able to eliminate type-1 diabetes in our lifetimes, and fewer and fewer people will have to suffer with a lifetime of management of a terrible, and once-deadly chronic disease.
God willing.
You can read the study here:
Edit:
They used rATG for induction and they do require sirolimus plus tacrolimus maintenance.
The side effects are usually easily managed, and if they're not for some individual, that patient can just go back to being diabetic.
When artificial thymus cell work reaches maturity, islet transplantation will be among the first therapeutic beneficiaries.
Or maybe this approach works, albeit with scaling issues to overcome:
Quote
Kenny Workman
@kenbwork
This is effectively a cure for type 1 diabetes. Autologous, (chemically) reprogrammed iPSCs were engineered from a patient's fat cells and injected back into her stomach. After ~2.5 months, she no longer needed insulin and now enjoys ice cream + candy like a normal person.
Fingers crossed this will be a cure for many with T1D.
The flame of hope could be extinguished in the not too distant future.
The first daily supplement designed to slow aging at the cellular level.
are these patients on immunosuppressants for the rest of their lives?
It’s actually been solved for almost 30yrs. I had a client in a late 90s/early 2000s trial at the U of Minnesota who became and still is a FORMER type I diabetic. They did cadaver islets grafted onto liver (better blood flow). And THAT was borne out of prior animal trials. It’s
This one is very shocking to me. A co-op that used to work for me married a lady with type-1 diabetes. At the time they told me she wasn't likely to live to a ripe old age. They were both good friends of mine. Soon after the pandemic, she passed away. He only lasted a couple of
And now that it works, whoever fronts the $$$ to make it happen will make sure it keeps printing money.
There will be at least 1 other drug made in conjunction with this to address the increased likelihood of some other illness or potential for mortality that it just continues
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@ecique_![Image](data:image/svg+xml,<svg xmlns="http://www.w3.org/2000/svg" width="1200" height="630"><rect fill-opacity="0"/></svg>)
If there is hope for type 1, will there also be help for type 2, that you’re aware of?
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This is such an advancement in Medicine, improving the quality of life for many, as well as the mental well-being of 1000's of adolescent T1DM patients.
use your money and influence to get some of this shit.
Big Pharma is unlikely to fund a CURE.
Well established.
Will need someone else to bully this through.
Worth noting that the treatment requires immunosuppressive therapy so the body doesn't reject it. Being immunosuppressed is much worse than having T1D to start with. I did hear they had another trial going on without the immunosuppressents though.
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Shout out to who developed this drug candidate (VX-880) as well as the follow-up VX-264 which will hopefully obviate the need for chronic immunosuppression
This is good but variations of this result have been achieved for years now—the big hurdle these days is, instead, addressing immunosuppression. $SANA might be the leader here but others are working on it, too, with varying degrees of promise
Promising development, though extensive clinical testing will be a critical next step.
If I’m not mistaken doesn’t upping fiber intake substantially accomplish similar results for far cheaper without the necessity of patented high cost procedures?
Sana Biotech had some extremely promising results earlier this year as well.
Aw.... that's so Incredible! I hope it comes to be for all who have Type 1... Goes to show, we must NEVER EVER GIVE UP HOPE about anything. One can never know what's around The Corner 
The first daily supplement designed to slow aging at the cellular level.
Has the left started claiming having diabetes is a good thing, and curing it is ableist?
Seems like how they would respond.
Jesus, this made me burst into tears. I really fucking hope there is something in this. YESS!!!
i'm hoping for this, im a rare type 1 diabetic, i got it from a allergic reaction to p*n*s*l*n .
great info thank you for sharing
Ćwierć wieku temu czytałem w Wiedzy i Życiu, że lada moment będzie można wyhodować sobie nowe zęby dzięki komórkom macierzystym. Przestałem zatem chodzić do dentysty-sadysty. Wciąż nie można wyhodować sobie nowych zębów a starych została mi już tylko połowa.
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@ecique_
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@ecique_
Were these T1s still producing any insulin? Would this work for long-term T1s who haven’t produced any insulin for decades? So many questions …
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@ecique_
JMIR Bioinformatics and Biotechnology invites submissions for our #ThemeIssue, “Artificial Intelligence in #Oncology.” Pave the way for a future where AI plays a pivotal role in advancing cancer research.
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@ecique_
You are way overselling this. Pancreatic transplants are already a thing but you have to take immunosuppressants. You seem nonchalant about immunosuppressants.
These take a decade to come to fruition if they ever do, and people die in the interim.
This is beautiful! Would love to see this for chronic kidney disease and others
Are they also on an immune suppressant though? If not this isn't a good cure.
Big pharma will do something to screw this up. They've spent millions creating all these diabetics....
Awesome news.
This is what the goal of healthcare should be all about: cure, not endless "treatment"
#CallForPapers JMIR Bioinformatics and Biotechnology invites submissions for our #ThemeIssue, “Artificial Intelligence in #Oncology.” Pave the way for a future where AI plays a pivotal role in advancing cancer research.
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hubs.la/Q02GcFrn0
@ecique_
JMIR Bioinformatics and Biotechnology invites submissions for our #ThemeIssue, “Artificial Intelligence in #Oncology.” Pave the way for a future where AI plays a pivotal role in advancing cancer research.
March 31, 2025
hubs.la/Q02GcFrn0
@ecique_Amazing results! Hopefully this could eliminate the overuse of long-acting insulin which can lead to metabolic encephalopathy.
It’s devastatingly painful and frustrating to watch your loved one die of DM I, metabolic encephalopathy. Wishing you much success with your continued
i dont believe it.
pancreas is notoriously, low on vascular and lymph structure.
FUCK YOU
WEVE BEEN "ON-THE - VERGE" OF CURING DIABETES FOR 50 years.
Read about islets 20 years ago. USA has been behind in development because Eli Lilly makes billions of dollars selling their insulin. Big Pharma doesn’t want a cure.
If you need anyone for your trials…my 24 year old daughter, type 1 since 13, lost a kidney in car accident due to low blood sugar. She doesn’t feel her lows. Thank you for your life saving research.