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There is another weight loss pill out there—oral semaglutide (i.e., oral Ozempic)—but it's much less effective, has worse side effects, and it requires you to take it on an empty stomach.
This simple pill crushes that in competition.
Now weight loss is coming to the masses.
Have you seen the recent speculation that they might qualify for the new FDA “commissioner’s priority waiver” or whatever and get a 2-month review? that is, it could be approved by the year end. I don’t put much stock in it, but it would certainly be interesting.
At a comparable dose, considerably better (maybe, say, 50%). At the highest dose used in trials, they're tied, but Rybelsus has a lot worse side effects, so it's hardly comparable.
Availability and price is more important than a few percentages more or less better
Eli Lilly has been stockpiling and building up production facilities to be able to undercut Novo Nordisk on price and have an enormous launch.
Is the effectiveness specifically against Ozempic, or is it against the latest class of GLP1s?
I am comparing it to semaglutide. The efficacy shown in the chart is just its efficacy, irrespective of any sort of comparison.
One a day pill seems like more of a pain in the ass than once a week injections
Instead of taking pill for weight loss, modify your diet ( eat right and healthy), engage in physical activities, these are more effective than any medication for weight loss.
due to set-point weight theory would someone hypothetically just take the pill forever to maintain reductions? genuine question
If it has the same anti inflammatory effects, blood pressure reduction and cholesterol reduction that the shot gives, I’ll certainly switch.
Just imagine if you told medieval Europeans, who lived through famine after famine … that someday everyone would need to take a weekly injection to actually STOP eating …
Orforglipron isn’t the droid you're looking for: it's a small molecule (i.e. non-peptide) version of semaglutide (Ozempic), functionally.
The big kahuna for Eli Lilly will be Bioglutide - a quadruple GLP-1 agonist that can also be taken orally. Currently in stage 2 testing...
Compare it to $VKTX data which had 8-9% on low dose( comparable to highest dose here) and 12% on high dose . You will thank me later.
I'm not as fat as the average American, but I could lose 15lbs. Some days I'm hungry all day - eat 2500 calories and still feel like I've eaten nothing. Some days I eat nothing until 3-4pm. A pill that gave me a consistent level of hunger every day would be life changing.
What is this going to cost on Mark Cubans cost plus drugs dot com??
Or you can just use nicotine orally 8-10mg x10 daily as needed and go for a 45 min walk daily.
I'm dreaming medication like this could save billions for the public healthcare system in Australia
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Game changer if true. Wonder how pricing and access will compare to injections though.
Actually I just checked. Novo Nordisk lost 57 percent of the market cap in one year
a few companies have sold these off label for the past year by compounding... but this makes it more legit for sure.
So like does this mean people don’t actually have to die to be thin? What a novel concept.
GIF
Bad news for Denmark. It was about time. Those 8 billion fighters that they ordered from Italy are gonna come through their nose.