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normally, DBS is used for things like parkinson’s by stimulating motor-related brain areas.
but in this study, researchers targeted the lateral hypothalamus (LH), a region better known for controlling hunger and arousal.
and it WORKED
one participant said: “i feel the urge to walk.” imagine hearing that from someone who’s been partially paralyzed for years
they didn’t just regain motion during the stimulation. the effects lasted even after the device was turned off.
this is neural rewiring.
let me break it down:
- DBS in the LH taps into surviving brain-spine connections.
- stimulation reorganizes these pathways, enabling walking.
- in animal studies, it even strengthened the remaining connections over time.
we’re literally hacking the brain
what’s crazy is that they paired this with precision surgery and advanced brain mapping to ensure they hit the exact right spot.
the result? participants could walk, climb stairs, and regain autonomy in ways that seemed impossible just a few years ago
this isn’t just about spinal injuries. this is proof that the brain can adapt and heal itself when given the right push.
it opens the door to treating a whole range of neurological conditions. stroke, parkinson’s, multiple sclerosis, you name it
we are entering the era of biotech.
what used to be science fiction is becoming reality:
- we can repair the brain and nervous system.
- we can restore mobility.
- the next step? using this tech to defeat not just disease, but even aging.
the future looks like this:
- combine dbs with spinal implants to treat even complete paralysis.
- integrate with brain-machine interfaces for direct control over prosthetics.
- eventually, we unlock the brain’s full potential.
we’re becoming limitless
it's also true that these are still the early days
- only 2 human participants so far.
- focused on incomplete injuries for now.
- scaling this to more people will take time, funding, and more research.
still, the trajectory is clear: we are winning
what excites me most is what this represents:
- we’re no longer at the mercy of biology.
- we’re rewriting the rules of what humans can do.
- and soon, the only frontier left to conquer will be aging.
the future is going to be extraordinary
every step forward like this reminds me that we are on the brink of curing paralysis, erasing disease, and maybe even defeating death itself.
if this isn’t exciting to you, idk what to say.
biotech is the revolution. we’re just getting started
So essentially they just retrained another part of the brain?
Bro I am sure this means one can "load up" knowledge following a similar approach
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Wait, they hacked a different area of the brain to rebuild movement??? WHAT? Thats insane
Sounds like it might only work in this case? The new area was where the brain attempted to regrow movement, but needed help?
Or did they hack a new brain region do an arbitrary task?
they didn’t just assign a random task to the lh. they amplified its natural but underappreciated role in movement control. it’s both specific to the brain’s recovery attempts and a proof of concept for hacking brain plasticity. mind-blowing.
Incredible!
We're getting closer to the era where neural interfaces become as common as smartphones, where we upgrade our brains like we upgrade our tech.
“There is a problem with getting people in the pipeline.”
How do neurodivergent people interview better in a neurotypical world?
Holy shit! Vittorio, this is amazing, thanks for sharing!
This is the beginning of a major revolution in the field of neuroscience.
i don't know if you've seen the work of and his lab... this remind of of that... we are finding more and more that the whole body, given the right signals, can be very plastic... loving this 
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"they targeted a new brain region for movement"
smh now we gonna have duplicate files in our brain too 
Read or listen to “The Brain That Changes Itself” an amazing look into neuroscience and brain plasticity. They discuss other similar discoveries in a very interesting and approachable way and how this knowledge had been set back.
This is simply incredible! Sounds like bypassing the injured neurons by passing connections through the intact healthy neurons. Explains all the stories of “he’ll never walk again…”, “but I never gave up and I wanted it more than anything, then I walked!”
Imagine the implications of using the hypothalamus to help other forms of learning.
Biology currently works against modern life.
Rewiring the brain to make your job as exciting as sex,
and developing a real hunger for learning.
This month's advancements and developments in dialysis are just a click away. See what your peers are researching, learning, and discussing at "In Case You Missed It!" on .
The researchers wanted to understand how the brain helps recover the ability to walk after a spinal cord injury. Spinal cord injuries can cause paralysis, but some people are able to regain the ability to walk over time. The researchers wanted to find the key regions in the brain
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Its amazing, but it also requires very long rehabilitation and training. It doesn't just "work" out of the box.
My father in-law currently using a DBS, this is great news, the future is going to even more amazing than we can imagine!
GIF
Imagine being able to diagnose diseases in seconds with just a sniff.
Researchers at the University of Notre Dame are working to do just that, thanks to an innovative device that can detect smells at a sensitivity of one part per billion.
There's a company called helius medical that IA able to achieve remarkable results with tongue simulation, resulting in increase neuroplasticity resulting in functional cures like balance issues and injuries.
Literal new neurons form and new pathways to make up for damage.
There's that famous question 'what are the smartest people geeking out on during the weekends that will eventually change the world' (computers in 70's, internet in 90's, crypto in 2010-2015, etc) and I think the answer right now is unequivocally biohacking/health optimization.
More brain-related white pills
Quote
Andrew Payne
@Andrew_C_Payne
E11 Bio is excited to share a major step towards brain mapping at 100x lower cost, making whole-brain connectomics at human & mouse scale feasible (
→
→
). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 
→→). Critical for curing brain disorders, building human-like AI systems, and even simulating human brains. 1/N 
Absolutely incredible stuff.
And people ask my why I’m so happy and energized @ 6 am.
The future is glorious!
and renowned ophthalmologist Jonathan Lass, MD, explore groundbreaking innovations in eye care from pioneering reading centers to advances in corneal transplants and treatments for macular degeneration.
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"Hey brain part. I know you're supposed to watch the stomach, buut we need to you watch the legs now too"
"OKAY, NO PROBLEM!"
how does this work? doesn't paralysis due to spinal cord injury (SCI) means the motor nerves are cut and the brain cannot communicate to the extremities? makes sense for traumatic brain injury (TBI) but for SCI?
The latest medical breakthrough against joint pain and stiffness
Broooooooo
Is this the world's first intentional and directed reformatting of cognitive association???
Reallocation of biological storage space???
This Is well within the limits of biology plus visualization, but it’s nice there’s a simple procedure that can help people who will never believe that, but will be happy to have their insurance pay for this.
Does this mean I will soon finally be able to use technology to crimp walk
and renowned ophthalmologist Jonathan Lass, MD, explore groundbreaking innovations in eye care from pioneering reading centers to advances in corneal transplants and treatments for macular degeneration.
