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In the past, we looked hard at both addiction and obesity, searching for any path to better outcomes in the research. I became convinced each was so intractable that the only solution would be pharmacological. Lo and behold, one medicine does both and it had already been created.
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Eric Topol
@EricTopol
A 40-50% reduction of opioid overdose or alcohol intoxication with GLP-1 drugs among >1.3 million Americans with history of opioid or alcohol use disorders, respectively onlinelibrary.wiley.com/doi/full/10.11
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David Watson 🥑
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With GLP-1s becoming so popular I can’t help but wonder or worry if there may be long-term negative consequences we don’t yet understand.
I would like this to be true, but it’s almost certainly not. There are few drugs that fix multiple things and few drugs without major trade offs and very few (zero?) with both. I’d bet heavily this won’t replicate in RCT.
I had the same epiphany four years ago with a range of conditions, all driven by obesity. I wonder if at some point someone will suggest putting it in the water. My great fear is that it also inhibits many of the traits that make us human.
I love the irony that a solution to two seemingly intractable issues was hiding in plain sight. Kudos to the researchers and scientists who persisted in exploring the potential of GLP-1 drugs. A game-changer for addiction and obesity treatment?
Did y’all ever consider litigating the constitutionality of the war on drugs, the possibility of legalizing all currently prohibited substances & replacing them w/ a regulated & taxed safe supply, and providing people w/ a bar-like establishment where they can safely consume?
We shouldn't expect Intoxication/Overdose | Prescibed to be so high at month 0 if there wasn't confounding variables like Prescribed | Wealthy