The impact of air pollution particulate matter 2.5 (PM 2.5) on the brain and lung
1. What is PM 2.5 and its constituents?
jci.org/articles/view/
Conversation
2. In today an important report on PM 2.5 increasing the risk of Parkinson's disease (PD) with dementia (Lewy bodies, LBD) with 3 parts (A,B,C)
A. Higher risk in >56 million Medicare population with chronic PM2.5 exposure for PD and LBD
science.org/doi/10.1126/sc
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B. Chronic PM2.5 exposure in the mouse model led to brain atrophy, cognitive deficit and alpha-synuclein pathology in other organs
C. PM2.5 induced a conformational change of alpha-synuclein that is neurotoxic, recapitulated LBD transcriptomics, and injected to mice, led to cognitive impairments like Lewy body dementia
This week's review of particulate matter air pollution on the respiratory system jci.org/articles/view/
