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The problem is that adding things to GLP-1RA treatment might lead to more side effects and worse adherence as a result.
But that seems to not be a concern with a low-dose myostatin inhibitor: added side effects only become concerning with more advanced treatment.
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The weight loss that comes with using GLP-1RAs is already similar to normal weight loss compositionally.
These new drugs thus present with an interesting prospect: that pharmacotherapy-driven weight loss will soon be superior to normal weight loss!
Bodybuilders--many of whom currently use GLP-1RAs--may also soon start using anti-activin and myostatin inhibiting drugs, perhaps even without GLP-1RAs.
Doing so would enable massive muscle gains at a rapid pace.
The world of bodybuilding might soon be forever changed!
To be sure, these findings are not without precedent and the possibilities have been raised before.
For example, Eli Lilly's dual myostatin/activin inhibitor bimagrumab has shown considerable success in trials.
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Crémieux
@cremieuxrecueil
I found another trial and noticed fat mass and lean body mass were reported in their supplement.
The bimagrumab group ended up with significantly higher LBM and less fat. The treatment effects for fat was significant and for LBM, it was marginal.
Small replication! x.com/cremieuxrecuei…
The changes these drugs achieve might also be cheap.
GLP-1RAs are already very cheap. For example, semaglutide only costs about $15 per month in the U.S. if you do a good job sourcing it.
Details: cremieux.xyz/p/how-to-get-c
Trevogrumab on the other hand tends to be far more costly right now.
When I asked, the scale of infusions of this stuff is at about 10mg/kg for low-dose arms, so *very* costly right now.
But this will be released for weight loss--there are plans to bring costs way down.
The future of weight loss is near! The future of bodybuilding might be too!
Sources:
newsroom.regeneron.com/news-releases/
You wrote that this drugs done cause muscle loss more than expected for weight loss in general. How do you interpret these data? Does it change your muscle loss analyses?
They don't cause more muscle loss than normal.
As the thread states, adding in a myostatin inhibitor makes this weight loss superior to normal weight loss.
Most fitness advice out there isn’t made for femboys or trans women.
You don’t need to get big or bulk up
You need a plan that fits you, gets the results you want, and will make you feel good
Yes, but not at anywhere near a reasonable cost. For a mere one-off 100mg infusion, you'll end up paying >$10,000.
Try to read BEFORE commenting.
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Crémieux
@cremieuxrecueil
Replying to @cremieuxrecueil
The problem is that adding things to GLP-1RA treatment might lead to more side effects and worse adherence as a result.
But that seems to not be a concern with a low-dose myostatin inhibitor: added side effects only become concerning with more advanced treatment.
The Regeneron story is a really interesting one:
If they scaled those two antibodies to the potential market, it would require a non-trivial amount of the entire antibody bioreactor capacity in the world.
Unrelated but I do want to see the long term cardiac data there.
Same. The cardiac effects are my biggest worry. If the drugs are only safe during weight loss rather than also being safe during attempts at weight gain, that's still nice, but not quite revolutionary.
The other big worry I have is about the potentially absent strength benefits.
Most fitness advice out there isn’t made for femboys or trans women.
You don’t need to get big or bulk up
You need a plan that fits you, gets the results you want, and will make you feel good
Honestly really excited for the adjustments because while I’m on wegovy .25mg, I’d really like a smaller dose. I’m the girl who has severe rheumatoid arthritis and semiglutide has been helping me
1.3% of phase 2 trial participants died during the trial from cardiac related issues
always wondered why myostatin regulators weren’t a thing. that would be the quickest way to build muscle. ozempic for muscle.
i guess they are a thing and i should do some reading.
Lots of peptide users have been mixing them for synergistic effects for years. Looks like data is finally starting to catch up. I would like to see them mix it with tesamorelin.
Most fitness advice out there isn’t made for femboys or trans women.
You don’t need to get big or bulk up
You need a plan that fits you, gets the results you want, and will make you feel good
An anti-activin-myostatin inhibitor stack can produce steroid-level gains, much more safely
The day they got the generic I will try it, until then I dont wanna do the homemade stuff you posted a few times lol
Most fitness advice out there isn’t made for femboys or trans women.
You don’t need to get big or bulk up
You need a plan that fits you, gets the results you want, and will make you feel good
not sure if its the same studies, but dr. mike is telling about similar thing
Most fitness advice out there isn’t made for femboys or trans women.
You don’t need to get big or bulk up
You need a plan that fits you, gets the results you want, and will make you feel good
I am on Ozempic and my life is way better. The reduction in inflammation in my body is wonderful. My mind is sharper. I just generally feel better despite not losing much weight.
epitogrumab is more impressive and FDA will approve it in august
