This vial contains a new drug called PAC-3310. It was designed by ChatGPT, and I synthesized it in a chemistry lab I built in my garage.
PAC-3310 is a new selective M4 muscarinic receptor agonist for treating schizophrenia - similar to the recent breakthrough drug Cobenfry, but improved. (1/7)
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1 in 4 people with schizophrenia don’t respond to any existing drugs/treatments. In 2024, Cobenfry made waves by becoming the first FDA-approved schizophrenia drug with a totally new mechanism. Rather than blocking dopamine receptors like all previous schizophrenia drugs, it
An alternative, more direct strategy that avoids the side effects of Cobenfry altogether is to design the muscarinic agonist to be ‘subtype-specific’ - that is, activate only M4, and not any of the other muscarinic receptors. This is exactly what PAC-3310 does. (3/7)
My new drug PAC-3310 improves on Cobenfry by exhibiting a much better selectivity profile across the five muscarinic receptors. In functional cell assays, PAC-3310 has nanomolar potency for M4 (EC50 = 97 nM) and >100x selectivity over M1, M2, M3, and M5 (EC50 > 10 uM for each).
When administered to mice, PAC-3310 significantly reduces MK-801-induced hyperlocomotion, demonstrating that it has antipsychotic effects in vivo.
Moreover, at doses up to 10x the effective dose, PAC-3310 produces none of the side effects typical of non-selective muscarinic
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Finally, PAC-3310 exhibits excellent pharmacokinetics (oral bioavailability > 70%, brain/plasma ratio > 0.5, plasma protein binding < 80%) and manufacturability. (6/7)
PAC-3310 is the second drug to come out of my AI-enabled home drug discovery lab, the first being PAC-832 for Alzheimer’s disease which I announced 2 months ago (x.com/DouglasYaoDY/s). I heavily utilized frontier AI models and liquid-handling robotics to develop both drugs.
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Douglas Yao
@DouglasYaoDY
This vial contains a new drug called PAC-832, which I recently invented to treat Alzheimer’s disease. It is the world’s first selective GalR1 antagonist.
I designed and synthesized PAC-832 in a chemistry lab I built in my garage. (1/16)
Stop focusing on pointless things like schizophrenia and please lock in on Male Pattern Baldness
"you're right to push back on that and I do apologize. Yes, this is actually lethal"
Believing you single-handedly cured schizophrenia on a commercial laundry folding table in a garage is, ironically, a classic symptom of schizophrenia.
Babe are you okay you barely touched the psychiatric medication I synthesized in the garage for you
You should ingest it, on video, and document your body’s reactions. Prove to us that AI is actually useful. Come on Douglas, don’t be scared, put the ChatGPT research chemical in your mouth, on video.
Very cool and interesting. Can you create one that induces schizophrenia? Asking for a non-government associated friend.
girl this is very impressive and all but i’m not sure the that a schizophrenic person will take well to taking a drug designed by ai and cooked up in someone’s garage
